Naucni Radovi

Efikasnije dejstvo kompletnog ekstrakta cvetova kanabisa u odnosu na izdvojen kanabidiol (CBD)

Autori – Ruth Gallily, Zhannah Yekhtin, Lumír Ondřej Hanuš
The Lautenberg Center for General and Tumor Immunology, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel; Department of Medicinal and Natural Products, Institute for Drug Research, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel
Email: ruthg@ekmd.huji.ac.il

Objavljeno: 10. 02. 2015.

Kanabidiol (CBD), jedan od glavnih sastojaka Kanabisa, pokazao se kao veoma snažan lek koji deluje protiv zapaljenja i anksioznosti bez psihotropskih efekata. Međutim, kada se daje intraperitonalno ili oralno, kao pročišćen proizvod, primećena je reakcija u obliku zvona koja ograničava njegovu kliničku upotrebu. U ovoj studiji, proučavali smo na miševima protivupalnih i antinosiseptivne aktivnosti (smanjenje osetljivosti na bolne stimuluse) standardizovanih biljnih ekstrakata izvedenih iz Cannabis sativa L, klona 202, koji je veoma bogat CBD-om i skoro da ne sadrži psihoaktivne sastojke. U potpunoj suprotnosti sa pročišćenim CBD-om, ekstrakt klona 202 kada se daje intraperitonalno ili oralno, obezbeđuje jasnu korelaciju između protivupalnih i antinosiseptivnih odgovora i doziranja, sa pojačanim odgovorom kod povećanja doza, što ovo biljno lečenje čini idealnom za kliničku upotrebu. Ekstrakt klona 202 je umanjio oticanje šapa kod miševa indukovano zimosanom, kao i bol, i sprečio proizvodnju TNFa (Tumor nekrozis faktora) in vivo. Vrlo je verovatno da se druge komponente iz ekstrakta udružuju sa CBD-om da bi se postiglo željeno anti-inflamatorno dejstvo koje može doprineti prevazilaženju reakcije u obliku zvona koji se javlja kod pročišćenog CBD-a. Iz tog razloga sugerišemo da je ekstrakt Kanabis klona 202 (Avidekel) superioran u odnosu na CBD za lečenje upalnih stanja.

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Izvor: http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=53912#.VW3OqVKHgvz

Prevod Slobodan V. Petrović i IRKA tim

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