Endokanabinoidni sistem i kanabinoidi

Zločin protiv Čovečnosti 2016 ( pismo Dr. Roberta Melameda )

Dr Robert Melamed, o evoluciji i ulozi Endokanabinoidnog sitema i CB receptorima i kanabisu kao jedinom mogućem načinu za dalju evoluciju, kojoj trenutno prisustvujemo i korporativno-političkim otporima koji trenutno sprečavaju oslobađanje biljke, ljudi i čovekovog evolutivnog potencijala. Tekst je na engleskom, deo je naučno teoretske studije, dobili smo ga zahvaljijući ljubaznosti Dr. Melameda, koji je nedavno gostovao na seminaru u Beogradu

The crime against HUMANITY

To Whom it May Concern, the following presentation is given in support of human evolutionary freedom. This natural process is threatened by backward looking people (BLPs), a primitive population driven by a hypersensitivity to stress, caused by insufficient endocannabinoid activity and resulting in ignorance, fear, and greed as they continue to harm others who think differently from themselves. Those in positions of power, who choose to deny the basic truths and continue to violate nature and associated fundamental rights described here in, will be subject to the global indictment before the World Court for crimes against humanity. Every Article of the Declaration of Human Rights has been violated by cannabis prohibition.The Physics of Life,

The earth is constantly bombarded by electromagnetic waves that, in conjunction with the heat of the earth, have powered the chemical conversions that led to the emergence of life. Nobel laureate Ilya Prigogine pioneered a new form of physics known as far from equilibrium thermodynamics. His work is based on the concept that flowing energy naturally organizes matter. Flow dependent dissipative structures naturally form because they generate more entropy to their surroundings than would occur in their absence. Hence they are consistent with the second law of thermodynamics. Consequently, for the first time in human history, we have a theoretical framework for understanding life, its emergence and it’s evolution.

The emergence of life from the inorganic prebiotic “soup” was a far from equilibrium phase change, as was/is also the case with the emergence of new species, or their disappearance with extinction. With the evolution of vertebrates, a new homeostatic mechanism appeared, the endocannabinoid system. The endocannabinoid system homeostatically regulates all human body systems (circulatory, digestive, endocrine, immunological, neuromuscular, skeletal, reproductive and skin) from conception until death!

The CB1 receptor, responsible for the euphoric effects of cannabis, regulates free radical production by regulating ion channels, in particular calcium. Consequently, they control all forms of energy-requiring cell activation, i.e., muscle contraction, nerve conduction, endocrine hormone production, etc., essentially cell differentiation as they drive the evolution of the human brain. Additionally, free radicals are critical determinants of the various forms of cell death. The probability of cell death, apoptosis or necrosis (including numerous subdivisions), is ultimately determined by the destructive free radicals that are naturally metabolically produced, or brought into the system from outside: sunlight and all forms electromagnetic radiation to which life is constantly exposed.

The CB1 receptor is found everywhere in the human body, and composes the most abundant neurotransmitter system in the human brain (not taught in medical schools). It allows for the fine-tuning of energy production via the dangerous, but efficient free radical producing electron transport system. As a result, the CB1 receptor has facilitated the development of the human brain, characterized by complexity and hence, distance from equilibrium. All cellular differentiation is promoted by efficient energy production.

The CB2 receptor activation turns on beta-oxidation of fats and makes energy inefficiently, but safely. Concomitant with fat burning, cells initiate autophagy, a recycling mechanism, by which cells eat their free radical damaged components and recycle them. Fat burning cells become less differentiated as they try to repair themselves. Drug resistant cancer cells and their metastasis are possible consequences.

By regulating the fuel source, and hence differentiation state of cells, they can be made more or less susceptible to dying. Consequently, cancers, infections (especially viral), and the aging process itself, can be regulated by manipulating energy flow, and hence free radical production with cannabinoids.

Since evolution is a direct manifestation of the creative force that permeates the universe the underlying science is the guide by which we should live our lives. Our religion is Evolutionism (see Appendix I) and is the basis of the Church of Evolving Consciousness.

Members our church periodically perform their anonymous sacramental duties to aid our fellow human beings suffering from illnesses that naturally result from insufficient cannabinoid activity. Both scientifically and experientially, human suffering can be dramatically reduced through the consumption of this essential nutrient. The cannabis sacrament, containing sufficient THC cannabis extract, i.e., the oil of life, must be freely available to all human beings desiring its healthful benefits to meet an individual’s unique needs.

Appendix II provides the references for the science that is further elaborated into Appendix III. In accordance with the Declaration of Human Rights (see Appendix IV) We the FLPs of the world demand that our basic human right to use cannabis-based medicines be unrestricted, in accordance with our Fundamental Human Rights.

Appendix I


“What is life?” is a question everyone considers. As the principles of far from equilibrium thermodynamics were discovered, they have become the basis of the religious beliefs by aware people globally, how we relate to the universe. Now, for the first time in human history, the process of life can be understood from a scientific point of view that can serve as a guide for human behavior. Our faith is in the validity of science, our belief system is known as Evolutionism, We are Evolutionists.

Surprisingly, evolution has selected for marijuana-like compounds to play a critical role in maintaining human health. The appropriate use of marijuana promotes human health. Hence, its appropriate use is thus mandated by Evolutionism since evolutionists strive to do what scientific facts suggest is healthy for themselves, their family, their community, their country and their planet. Currently, we are deprived of our religious freedom. We cannot practice our fact-based religion because people of other, typically faith-based, religions deny the truth about this unique plant, and make laws contrary to fact despite its use as a component of the Holy Anointing oil specifically described in the Bible. Because we faithfully adhere to our religious principles, we are labeled as criminals!

All people make marijuana-like compounds known as endocannabinoids. Whenever anyone gets hungry, they are giving themselves the “munchies” with the cannabinoids that they produce, as occurs when a mammal nurses its young. In fact, cannabinoids control every system in the human body (cardiovascular, nervous, endocrine, immune, digestive, reproductive, excretory, musculo-sketetal). It is because of their all-pervasive activity that cannabinoids can impact on so many illnesses. Cannabinoids: kill many types of cancer cells, protect against Alzheimer’s disease, delay the onset and severity of auto-immune diseases such as arthritis, diabetes, multiple sclerosis and Crohn’s disease, and recently has been shown to both protect the heart from damage as well as to protect against, arteriosclerosis, they relieve pain, stimulate the appetite and promote sound sleep. Cannabinoids also regulate stress, learning and open-mindedness. Hence, we can predict that many followers of faith-based religions are deficient in cannabinoid activity, and are impaired in their capacity for open-mindedness. As a result, they make laws that are contrary to fact and freedom.

Before elaborating on our religious beliefs it is important to have a definition of religion. Here are some examples:

“Religion, sometimes used interchangeably with faith, is commonly defined as belief concerning the supernatural, sacred, or divine, and the practices and institutions associated with such belief. In its broadest sense some have defined it as the sum total of answers given to explain humankind’s relationship with the universe. In the course of the development of religion, it has taken an almost infinite number of forms in various cultures and individuals” en.wikipedia.org/wiki/Religion

“Any specific system of belief about deity, often involving rituals, a code of ethics, and a philosophy of life.” Thus we would include Agnosticism, Atheism, conservative Christianity, Humanism, Islam, Judaism, liberal Christianity, Native American Spirituality, Wicca and other Neopagan traditions as religions” www.religioustolerance.org/gl_r.htm

“An organized system of belief that generally seeks to understand purpose, meaning, goals, and methods of spiritual things. These spiritual things can be God, people in relation to God, salvation, after life, purpose of life, order of the cosmos, etc.” www.carm.org/dictionary/dic_p-r.htm

Far from equilibrium thermodynamics, as pioneered by Nobel Laureate Illya Prigogine, shows that flowing energy intrinsically has a creative capacity. This physical reality has manifested itself as chemical evolution, life and consciousness As such, these principles constitute the foundation of a belief in an abstract higher creative force that has parallels with other religious beliefs (GOD=generalized open system dynamics). These concepts are of particular interest to a growing number of people in a broad spectrum of fields, in particular those devoted personal growth, health, and the exploration of their minds. The principles of evolutionism provide a foundation, based on sound scientific principles for viewing life in a positive, and constructive manner. On the other hand they provide a unifying framework to challenge current laws that squander our resources and unconstitutionally restrict our basic human rights including religious freedom.

Basic Principles for Evolutionists

The universe has been expanding and cooling since the big bang. Regardless of what one posits to be responsible for these events, they appear to be governed by physical laws. Evolutionists see the Second Law of thermodynamics, as it pertains to far from equilibrium systems such as the Earth’s biosphere, as the driving force behind evolution. In contrast, those who deny evolution incorrectly apply the Second Law of Thermodynamics as it applies to equilibrium systems to justify intelligent design. Hence being an evolutionist does not exclude other religions beliefs unless they specifically exclude the belief in the evolutionary process. We now understand that whenever far from equilibrium systems are considered, where there is a negentropic potential, a source, and an entropic sink, where disorder increases, there is the possibility for spontaneous organization (creativity). In other words, as long as the entropy of the universe increases, the entropy of subsystems can decrease (the second law of thermodynamics). For example, our sun emits a spectrum of electromagnetic radiation that is rich in ultraviolet light. This type of light is of relatively high frequency and hence has greater information potential (high frequency) than does lower frequency light. The biosphere is powered by the information potential extracted from the higher frequency light. The earth re-irradiates infrared light back into the space. Infrared light is of a lower frequency and therefore has less information capacity. Evolution and all of its creative manifestations result from the process of acquiring and refining energy that comes from our sun and the expanding universe. Health can be measured by an organism’s or a population’s distance from equilibrium. The further from equilibrium an organism (population) is, the greater its flow dependent organization and state of health, ultimately meaning adaptability. In contrast, equilibrium is the state of maximum disorder or greatest entropy. Thus, as an organism (population) approaches equilibrium, health declines. The opposite is also true. The move from equilibrium moves an individual (population) towards health. Therefore, an intelligent life form would conclude that it must move further from equilibrium if health and survival were of value. We must uncover, as individuals, how to apply these thermodynamic principles to manage our ecosystems and individual lives in sensible, healthy ways.

What does this mean from a practical point of view? It is a personal search for an evolving understanding and application of the principles under discussion. It requires lifelong learning. This process becomes a fulltime perspective as one applies and refines the simple concept of moving further from equilibrium to all aspects of ones existence. Our life’s energy becomes more functionally applied as less energy is wasted on primitive nonfunctional organized structures that waste life’s potential. All things that healthy individuals in a healthy society value conform to the paradigm that there is value in the move from equilibrium. Our planet, its ecosystems, nations, communities, families all evolve by these principles.

Appendix III

A Far From Equilibrium Thermodynamic Perspective of Metabolically Generated Free Radicals as the Foundation of Homeostasis
Robert Melamede, Ph.D., Phoenix Tears Foundation, Denver CO, Executive Director Masada (Jamaica)

Whenever there is an abundance of paradoxes that emerge from studies in a particular field, the need for a new conceptualization is indicated. Consistently, when trying to understand life, much apparently contradictory data has been generated. The linear, machinelike, reductionist thinking that characterizes Newtonian physics is built upon time reversibility as a basic quality of nature despite its obvious contradiction with real world experiences. This foundational logic was carried into the development of modern quantum theory, where probabilistic wave functions collapse into reality only when a measurement is made. A significant problem with this type of old thinking is that from a simple statistical perspective, life is too improbable to exist. Obviously since life does exist, new underlying principles are required. Fortunately, Nobel laureate Ilya Prigogine provided the foundation for new thinking.

When one considers the process of evolutionary adaptability, the starting point should be a physical chemical understanding of what is adapting. A far-reaching hypothesis regarding the physics of life will be presented that embraces the endocannabinoid system as the solution for needed enhanced adaptability, synonymous with greater negentropic complexity. The emergence of vertebrates heralded a non-linear enhancement of adaptability as evidenced by enhanced brain, bone, skin, and immune system replacing their more restrictive (less adaptive) invertebrate counter parts. All life is composed of dissipative structures that resonate across biochemical scales as interacting limit cycles. All levels of biological organization are encompassed.

Coincident with vertebrate emergence, the CB1 receptor first appeared. How did this receptor, which is found everywhere the human body, enhance adaptability at that critical time? A far from equilibrium perspective of life provides a coherent solution as to why the CB1 receptor became the natural solution to satisfy an evolutionary need for greater safe energy production (controlling free radical damage). As a result of the critical role played by the endocannabinoid system in human life, the cannabis awakening is spreading throughout the world. People have anecdotally discovered the profound health benefits of cannabis. Activating the endocannabinoid system (marijuana from within) inhibits all age-related illnesses including cancers. Furthermore, activating the endocannabinoid system provides a novel opportunity to control infectious diseases including HIV and Kaposi’s sarcoma.

Dr. Robert Melamede
Associate Professor and Biology Chairman UCCS (Retired),
CEO and President Cannabis Science (Retired),
Program Director Phoenix Tears, (Denver CO)
Executive Director Masada (Kingston, Jamaica))
Science Advisor, Spannabis (Columbia SA)

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